Lung Cancer Researchers and treatments in USA

Researchers Focus on Lung Cancer Treatment

Finding better ways to treat lung cancer is a priority for researchers in medical centers around the world. New therapies are badly needed because lung cancer causes more deaths among Americans than any other cancer. Lung cancer is often difficult to treat, and most patients don’t have any symptoms until the cancer has spread too far to be cured.

Lung-MAP study

A new kind of large research study is currently testing 5 different experimental drugs at the same time, all for advanced squamous cell lung cancer.

Most research trials of new treatments test only 1 drug and try to figure out which patients might be helped by it. In the Lung-MAP trial, researchers are looking at the DNA from each volunteer patient’s lung tumor to find out what changes are causing it to grow. They are using the results of the DNA screening to assign the patient to the arm of the study that’s testing a drug designed to target those specific genetic changes.

Squamous cell lung cancer represents about 25% – 30% of lung cancer cases. Chemotherapyis the main treatment for advanced disease, but its effects are often limited. A goal of the Lung-MAP trial is to improve patients’ access to promising new drugs, as well as making it easier for researchers to find patients to help them test the drugs.

The trial is being conducted at more than 200 medical centers around the country. To learn more about the study or find a participating medical center, visit the Lung-MAP website or clinicaltrials.gov

 

 

Radiation therapy

Recent studies have found promise using radiation therapy to help some people with hard-to-treat types of lung cancer.

In a study by Dutch and British researchers, adding chest radiation to standard treatment with chemotherapy helped people with advanced small cell lung cancer (SCLC) live longer and reduced the chances of the cancer coming back in the chest.

The trial involved 498 people in the Netherlands, the United Kingdom, Norway, and Belgium with advanced SCLC who had improved with chemotherapy. They were randomly assigned to receive either radiation to the brain only, or radiation to the brain and chest.

After 2 years of follow-up, 13% of those treated with chest radiation were still alive compared with only 3% of those treated with standard care but no chest radiation. Also, 24% of those who had chest radiation survived for 6 months without their lung cancer getting worse compared with only 7% who did not have chest radiation. In addition, cancer came back in the chests of only 20% of those who had chest radiation compared with 46% of those who did not.

The study was published online September 14, 2014 in The Lancet and presented at the annual meeting of the American Society for Radiation Oncology (ASTRO) in San Francisco.

Another study presented at the ASTRO meeting found that a specialized form of radiation therapy might be a reasonable treatment option for some patients with early-stage non-small cell lung cancer (NSCLC) who aren’t healthy enough for surgery.

Researchers from the University of Texas Southwestern Medical Center in Dallas and colleagues studied 55 people with early-stage NSCLC. Surgery is sometimes part of the main treatment for these cancers, but these people couldn’t have surgery because they had other serious medical conditions. Instead, they received stereotactic body radiation therapy (SBRT), a type of external beam therapy that delivers high doses of radiation to the tumor in a short amount of time while limiting exposure to surrounding healthy organs.

Five years after treatment, 40% of the patients were still alive, and 26% still had no signs of any remaining cancer.

A larger study is going to look at whether SBRT might be a reasonable option even in patients who would be eligible for surgery.

 

Targeted therapies, immunotherapies

The US Food and Drug Administration (FDA) this year approved Zykadia (ceritinib) for a type of late-stage NSCLC. Zykadia is a kind of targeted drug that works by blocking a protein that helps cancer cells grow. It specifically targets cells with mutations (changes) in the ALK gene.

Only a small percentage of NSCLC patients test positive for the ALK gene mutation. Zykadia is intended for these people when the cancer has spread (metastasized), after they were treated with Xalkori (crizotinib), the only other FDA-approved drug that targets cells with a mutated ALK gene.

The FDA based its decision on a clinical trial of 163 people with metastatic ALK-positive NSCLC. All of them were treated with Zykadia. Tumors shrank in about half the patients, and the improvement lasted on average for about 7 months.

Perhaps the most exciting new approach to lung cancer treatment is the development of drugs that use the body’s immune system to fight the cancer. For example, cancer cells often have a protein called PD-L1 on their surface that helps them evade the immune system. New drugs that block the PD-L1 protein, or the corresponding PD-1 protein on immune cells called T cells, can help the immune system recognize the cancer cells and attack them.

In early studies, an anti-PD-1 drug known as nivolumab shrank tumors in about 1 out of 5 people with NSCLC, while a drug targeting PD-L1 (known as BMS-936559) shrank tumors in about 1 out of 10 people. Many of the tumor responses have been long-lasting so far. Larger studies of these and other, similar new drugs are now being done, but they are still only available in clinical trials.

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Software Recovery

The following is a transcript of an interview with Graham Henley, one of the founders of GetData and authors of Recover My Files:

Q; Why, if data recovery software technology is so readily available, aren’t the overwhelming majority of us aware that it’s possible?

Well basically it is because the button on the keyboard says “delete”. Most computer users take this at face value and think that when you press the delete button it’s gone for ever, which is not the case.

Also we have all become very used to the Windows Recycle Bin, where you can move files that you no longer want, but can get them out before you empty the bin. Many people still don’t realize that with data recovery, even when the Recycle Bin is emptied there is still an opportunity to recover the files.

Q: How is it possible to recover missing files without sending your drive out to a company and risk something happening to the drive? (Or….Why is it not necessary to send your drive out to a company to recover your files?)

Data recovery can be put into two categories …

  • when your computer hard drive is working perfectly, but you have deleted files, formatted your drive, or lost your data for some other reason. This is what is referred to in the industry as a “logical” problem.
  • when you computer hard drive has physical errors and some of the mechanical or electrical components of the drive no longer work, for example when you computer has been in a fire or a flood. This is what is referred to in the industry as a “physical” problem.

In many cases the data has been lost due to a “logical” problems and a software solution can be used to recover files. It is only if you drive has physical errors that you need to send it to a hardware recovery service.

Q: In simple terms, what is the technology that allows a computer owner to recover their files right there at their desk?

Data recovery is possible because of the way the Microsoft Windows operating system is designed. Historically Windows has been developed to maximize the speed of computer use. Permanent erasure of data, whilst possible, takes time.

Q: What was the technical breakthrough that allows us to do this now?

Data recovery procedures have improved rapidly in recent years. A lot of this is due to the need by law enforcement agencies around the world to deal with electronic evidence.

 

 

Q: Is the ability to recover files limited to conventional hard-drives, or can files be recovered from other types of drives or media on which information may be stored

Files can be recovered from many different types of media, including hard drive, USB drives and digital camera storage cards.

Q: What risks are there to downloading a software application and having it search and recover your missing or deleted files?

When you download files from the Internet to your computer you should always make sure the file comes from a trusted source, no matter what the software does. This is a good basic security policy for your computer and will protect you from such things like viruses and spyware.

If you are looking for data recovery software you should make sure that:

  • the software you use does NOT change the contents of the drive being searched. If the software does not work you want to be able to pursue other options to try and get your valuable data back.
  • It is possible that deleted data can be destroyed and not recovered. You should be able to identify that the data recovery software has recovered your data before you purchase it. Recover My Files does this by having a file preview window which allows you to view pictures and documents.

Q: What sort of files will the data recovery software find?

Recover My Files can find any type of deleted file, but it also has support for more than 200 specific file types file. There are two methods to data recovery:

1. Every file on a computer, even the deleted ones, is identified by a record in a table called the Master File Table or MFT. A files MFT record tells the computer the name of the file and also the location on the disk where the file is stored. Recover My Files reads these MFT records to find and recover deleted or lost files.

2. In some circumstances the MFT records can become corrupt or destroyed. In this situation Windows has no reference information to locate the deleted or lost files, however, Recover My Files can look for and find user specified file types by scanning the storage media and looking for a files unique structure, that is, it’s unique header, content and footer.

 

 

Q: Does it take long, and could I keep working on my computer while the data recovery software is working?

You should limit the use of the computer until data recovery is finished. The more you use a computer the more chance you have of writing data to the storage media and overwriting and destroying deleted files that could have otherwise been recovered.

In some situations data recovery can take time. With a very large hard drive of 200GB, it may take up to 15 hours to search the entire disk.

Q: How do I begin and stop the software searching?

Recover My Files if straight forward to use. There are basically four steps.

1. Decide what search you want to run according to your situation, for example whether you have deleted files or formatted your drive.

2. Select the drive that you want to search. If you can no longer see a drive letter, Recover My Files allows you to search a drive at a “physical level”, meaning that it finds drive in your PC, starts at the beginning and goes to the end, ignoring all drive letters on the drive;

3. Select the specific file types, if any, that you are looking for;

4. Start the search and preview and save the results.

Q: How will I know if the software has found my missing files?

You will be able to see the file names and click on the recovered files to preview them.

 

 

Q: What do I do once the software has found them?

Select the files that you wish to save and then save them to another drive. You need to activate the program in order to do this, which means purchasing an activation key from www.recovermyfiles.com. The activation key I given to you at the time of your purchase so you can save the files straight away.

Q: Can I use the data recovery software over and over, if I have future problems with missing files, or is it a once-off?

Once you purchase Recover My Files you can use it over and over again. An activation key is valid for installation on two computers, for example, a desktop and a laptop.

from: recovermyfiles.com

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Photographing The Stars is Like “Jumping in The Time And Space”

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Consider you made an enjoyable photo shooting last night including the Pole Star. Moreover consider you had a quality printout of the photograph then hanged it on a wall of your home… Congratulations! You traveled through time. The picture on your wall is at least from 450 years ago.

No, I didnt make a sentence with incoherency. If you took a star photo, the image you got belongs to hundreds of year ago ... Well then, how did it happen? You should know that the distance to earth of objects on the sky or in the universe, of we take the photos or see with naked eye, is calculated in terms of light years. Now, thinkabout the time it takes the light, in other words the image, arrives to us... Hundreds of years elapse in the earth before image of the star reaches us.

How is star exposure made?

After summarizing the sides of the matter like past, time and light, which sounds somewhat unfamiliar, we can switch to some practical information on photography. In this section, I will talk about a technique in which we adapt long exposure shoot to stars: Star Exposure.

The shutterspeed on our cameras ensures us freeze time in different sections. I usually clarify the matter to beginners using the example of blink of an eye. Consider that the duration when life enters increases while the eye of a person stays open. As you know, if you keep your eyes open beyond certain duration your eyes stream. Well, what happens in photography? If you are in a setting where is dark enough, if you keep your eyes open more, you see that everywhere lightens…

The shutter speed of cameras is similar. Long exposure is comparable to your friend who can keep eyes open to be able to see even in the dark. High shutter speed is your tiqueur friend who blinks continually... When exposing stars, we are going to imitate your friend possessing the most useless super hero power ever, who can keep her eyes open for a long time in order to be able to see in the utter darkness.

In order to be able to take a clear photo of a quick-moving object, we first of all need sufficient light and then a high shutter speed. On the other hand, in times when we need more light for exposure, we need a steady speed and a lower shutter speed. That is to say, not only time, but we also need a steady speed. In summary, while taking star photos, your camera should look at the sky longer without blinking or moving.

Sure, there are other things that we should take into consideration during long exposure. If you have ever flown at night, you should have noticed how strong the rising city lights were when you have looked down. Those city lights and similar light sources are the primary physical elements that we should avoid when shooting the stars.

Photographing The StarsIn case any light other than that emitted by the celestial bodies themselves enters in your photo frame, it will impair the quality of your photo or might completely damage your photo. Besides the light source issue, I should also remind that, using the lunar calendar we should prefer times when no strong light source like moon is quite close to Earth.

Moreover, because the shutter of your camera will have to be open for an average of one to three hours, it should certainly be stable in the meantime. If you don’t have a high quality tripod or if you cant keep your camera stable during exposure, it is of very low possibility that you will be successful.

I know that I am explaining a bit complicated, but don’t worry. I’m going to summarize. Let me give you a step by step guide about what you should take into consideration related to star exposure.

You must shoot away from city lights.

The sky should be clear and the Moon shouldn’t be at the top. Because you will make long exposure, you must have a tripod that can prevent camera shake. Carbon fiber ones can considerably reduce shake.

In order to prevent shakes whenever you press the shutter and in order to be able to use the ‘bulb’ mode if it isn’t taking place on your camera, you must have a cable trigger. If you want to convey the motion of stars on your photo, you might use longer exposure duration. If you want to shoot the stars as is, as points, you might use a much more shorter exposure duration.

Your ISO/ASA value should be as low as possible. Long exposure=sensor getting warmer=more noise. In order to avoid it we should use the lowest possible ISO values.

If they take place on your lens, you must turn off anti flicker and auto-focusing.

Photographing The StarsDo not attempt to increase aperture to values like f22, or you unnecessarily lengthen the wait time for hours.

Do not go desolate places posing risk for you just for the sake of moving away from city lights. If you are going somewhere like a village or town, do not forget to tell people that you are going to shoot. Otherwise, the owner of the territory that you entered in the night time is likely to assume what you are holding is a gun and react you! I should repeat that it is not a joke, but a serious warning.

You should set the exposure duration based on your experiences, the circumstances and the photo you wish to get. Do not afraid from trial and error. The above stated duration of one hour is exemplary.

Finally, you must use the sentences like “May be most of the stars that we see now went out a long time agoonly at romantic moments with your darling. Because, the stars within our visual space have millions of years to die and they will probably stay there after our planet disappear. If you are not making a telescopic shoot, you take the photo of past rather than of
the lost and gone forever.

As a last word, I should say that I wrote this article not as a scientist but as an ‘advertising photographer-director’ who is interested in space and science...

What is in our backpack?

Edelkrone SliderPlus Pro XL

Canon 5D Mark IV

Tamron SP 15-30 F /2.8

Tamron 70-200 F /2.8 Vi DC USD

Manfrotto MK055 XPro 3W Tripod

Canon 5D Mark IV

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High performance and safety come together in the Mazda 6 SW

As the size of your family grows, your needs also grow. However, needing more space does not mean compromising on performance and style. Keeping this in mind, the Mazda 6 Station Wagon is one of the best for all your family’s needs.

It’s smooth design and athletic look shows how sporty a hatchback can be. LED front headlights give the car a sharp expression and during night driving automatically direct light where you need it the most.

The luxurious interior design prioritizes the comfort of driver and passengers. Mazda Connect also enables you to remain online with your smart phone. The car’s 7” touch screen monitor and HMI control enable easy control while the efficient driving monitor enables you to follow your speed and navigation instructions without taking your eye off the road. This spacious model offers more than enough head and leg room along with a large space for your belongings.

mazda 6 sw

The Mazda 6 SW has been awarded 5 stars from the Euro NCAP safety test and the model is equipped with smart break support, lane keep assist, driver attention alert, rear cross traffic alert and blind spot alert systems all standard. Our test car had brand new Skyactive technology and a 2-liter diesel engine. The four-wheel drive produces 160 horsepower while fuel consumption was 7.5 liters average during my test drive. The car’s performance was much higher than my expectations and it certainly was the most pleasant driving experience I have had with a car in this class.

Basically, the wagon is practically the same as the vehicle upon, which it’s situated as far as its general outline and size. Where the models contrast is behind the C-column, where the vehicle’s boot clears a path for a curvier backside on the wagon.

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How Elon Musk Crushed Detroit in Ten Years

Before Elon Musk, For a considerable length of time, American carmakers had what many considered a definitive offering point in drawing in youthful buyers. Merchants may have showcased provocative Ford Mustangs with V6 motors, or GM trucks with favor sound frameworks and additional comfortable seats, yet in all actuality they were all offering something much more fleeting: flexibility.

Young people salivated over the idea of turning 16, getting a driver’s permit, and acquiring freedom from their folks. When of my discussion with these Ford administrators, the car business had as of now withstood endless dangers (the ascent of Japanese carmakers, the approach of new assembling rehearses, and the previously mentioned monetary emergency) however none were as squeezing as the way that another, generally cheap gadget now seemed to offer adolescents a recently discovered computerized flexibility that bested any simple contender. “The auto used to be the flag of adulthood, of flexibility,” a Ford official let me know at the time. “Presently, the flag into adulthood for youngsters is the cell phone.”

Maybe no industry has endured the disturbances of unpredictability very like the once staid and exhausting auto business. Those officials at Ford were to be sure right. While Detroit has constantly considered itself important, and effectively, as a town that made excellent questions out of steel, organizations in Silicon Valley have for quite a while been taking a gander at autos simply like another cell phone or application. Faraday Future, for instance, moved toward building an altogether new auto as less of an activity in equipment than in making programming, and how to update it later. Comma.ai, which was begun by a PlayStation programmer, constructed a $999 unit to make (nearly) any auto into a driverless auto. At that point there was self-driving start-up Cruise, which was gained by GM; and Zoox, a self-depicted mechanical autonomy start-up with $200 million in financing, which is likewise constructing an auto that can drive itself.

The dangers, obviously, now appear to originate from all over the place. The year 2011, all things considered, appears to be nearly pre-noteworthy by all accounts. That very year, TechCrunch had distributed a tale about a “youthful start-up” called Uber, which had as of late raised $11 million for a valuation of $49 million.

Elon MuskGoogle, which was consistently satirized for its apparently unrealistic journey to assemble an alleged “driverless auto,” conceded, with unique quietude, that the organization did not have any genuine clear arrangement. The Tesla Model S, the primary standard auto to hail from Elon Musk’s brainchild organization, wasn’t even out and about yet.

There are few individuals who could have anticipated what Silicon Valley would do to Detroit inside the traverse of 10 years. This week, for example, Tesla turned into the most esteemed automaker in the United States, overwhelming 108-year-old GM, in market valuation. This is only seven days after Tesla passed Ford. Who knows to what extent it will take before Tesla flashes by outside carmakers, including Honda, BMW, and Toyota.

Tesla has something no other auto organization can verge on offering its customers: Musk, who is loved by geeks all around. Indeed, even non-geeks know his identity, and let’s be realistic, what number of individuals in America know the name of some other auto organization C.E.O.? However while Musk can lightly switch a discussion midstream from driverless autos to computerized reasoning to extraterrestrial life, his divinations can now and again seem to be unadulterated buildup for what’s to come.

Which is another method for indicating out that Tesla has not yet absolutely won, in any event in the United States. Tesla just conveyed around 80,000 autos a year ago, contrasted and more than 10 million from GM. (Tesla, be that as it may, sold a more costly armada.) There’s additionally Uber, which, in any event on paper, is worth around $68 billion, or about $17 billion more than Tesla’s market capitalization. Uber doesn’t make and offer autos, however that may just involve time. What’s more, we should not overlook that Tesla’s stock is always being shorted by financial specialists who trust that Musk’s status has swelled its value, that Tesla proprietors are becoming tied up with the clique, that they are putting resources into a visually impaired guarantee of what Tesla may offer later on, not what it has sold before, or even the present. In any case, Tesla’s fast rising is yet another case of how rapidly a whole industry can be disturbed in today’s business advertise.

That lesson may be the most essential thing for financial specialists to consider amid the following couple of years. While Ford and GM were once among the surest wagers, the auto market is currently, no ifs ands or buts, a standout amongst the most unusual businesses in our economy. Nobody knows whether we will possess autos later on, summon them like Ubers, lease them, or relinquish them. Will they be controlled by sun based, hydrogen, gas, power, our natural liquids, or some new fuel being made in a lab some place? Will these vehicles go on streets, walkways, or fly through the air? What else don’t we know?

Similarly that Ford thought its greatest rival was the iPhone, there are likely many different organizations out there that could thump Tesla out of the lead position in a matter of moments by any stretch of the imagination. Perhaps Amazon gets into the self-driving-auto business (something I really do accept will happen one day), or Apple, Google, Volvo, BMW, Uber, or any number of original new businesses that none of us have ever even known about, is building a contending auto organization that in only a couple of years will be the most esteemed auto organization in America.

But then perhaps that is excessively oversimplified a thought. On the off chance that an iPhone can alarm Ford officials, one marvels what yet unfathomed item could overturn the new auto showcase. Henry Ford may come in his grave, yet Musk likely knows this great. It’s altogether conceivable somebody, some place is taking a shot at something we have never contemplated that could overturn Tesla. Until further notice, financial specialists are trusting that somebody is Elon Musk.

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