Lung Cancer Researchers and treatments in USA

Researchers Focus on Lung Cancer Treatment

Finding better ways to treat lung cancer is a priority for researchers in medical centers around the world. New therapies are badly needed because lung cancer causes more deaths among Americans than any other cancer. Lung cancer is often difficult to treat, and most patients don’t have any symptoms until the cancer has spread too far to be cured.

Lung-MAP study

A new kind of large research study is currently testing 5 different experimental drugs at the same time, all for advanced squamous cell lung cancer.

Most research trials of new treatments test only 1 drug and try to figure out which patients might be helped by it. In the Lung-MAP trial, researchers are looking at the DNA from each volunteer patient’s lung tumor to find out what changes are causing it to grow. They are using the results of the DNA screening to assign the patient to the arm of the study that’s testing a drug designed to target those specific genetic changes.

Squamous cell lung cancer represents about 25% – 30% of lung cancer cases. Chemotherapyis the main treatment for advanced disease, but its effects are often limited. A goal of the Lung-MAP trial is to improve patients’ access to promising new drugs, as well as making it easier for researchers to find patients to help them test the drugs.

The trial is being conducted at more than 200 medical centers around the country. To learn more about the study or find a participating medical center, visit the Lung-MAP website or clinicaltrials.gov

 

 

Radiation therapy

Recent studies have found promise using radiation therapy to help some people with hard-to-treat types of lung cancer.

In a study by Dutch and British researchers, adding chest radiation to standard treatment with chemotherapy helped people with advanced small cell lung cancer (SCLC) live longer and reduced the chances of the cancer coming back in the chest.

The trial involved 498 people in the Netherlands, the United Kingdom, Norway, and Belgium with advanced SCLC who had improved with chemotherapy. They were randomly assigned to receive either radiation to the brain only, or radiation to the brain and chest.

After 2 years of follow-up, 13% of those treated with chest radiation were still alive compared with only 3% of those treated with standard care but no chest radiation. Also, 24% of those who had chest radiation survived for 6 months without their lung cancer getting worse compared with only 7% who did not have chest radiation. In addition, cancer came back in the chests of only 20% of those who had chest radiation compared with 46% of those who did not.

The study was published online September 14, 2014 in The Lancet and presented at the annual meeting of the American Society for Radiation Oncology (ASTRO) in San Francisco.

Another study presented at the ASTRO meeting found that a specialized form of radiation therapy might be a reasonable treatment option for some patients with early-stage non-small cell lung cancer (NSCLC) who aren’t healthy enough for surgery.

Researchers from the University of Texas Southwestern Medical Center in Dallas and colleagues studied 55 people with early-stage NSCLC. Surgery is sometimes part of the main treatment for these cancers, but these people couldn’t have surgery because they had other serious medical conditions. Instead, they received stereotactic body radiation therapy (SBRT), a type of external beam therapy that delivers high doses of radiation to the tumor in a short amount of time while limiting exposure to surrounding healthy organs.

Five years after treatment, 40% of the patients were still alive, and 26% still had no signs of any remaining cancer.

A larger study is going to look at whether SBRT might be a reasonable option even in patients who would be eligible for surgery.

 

Targeted therapies, immunotherapies

The US Food and Drug Administration (FDA) this year approved Zykadia (ceritinib) for a type of late-stage NSCLC. Zykadia is a kind of targeted drug that works by blocking a protein that helps cancer cells grow. It specifically targets cells with mutations (changes) in the ALK gene.

Only a small percentage of NSCLC patients test positive for the ALK gene mutation. Zykadia is intended for these people when the cancer has spread (metastasized), after they were treated with Xalkori (crizotinib), the only other FDA-approved drug that targets cells with a mutated ALK gene.

The FDA based its decision on a clinical trial of 163 people with metastatic ALK-positive NSCLC. All of them were treated with Zykadia. Tumors shrank in about half the patients, and the improvement lasted on average for about 7 months.

Perhaps the most exciting new approach to lung cancer treatment is the development of drugs that use the body’s immune system to fight the cancer. For example, cancer cells often have a protein called PD-L1 on their surface that helps them evade the immune system. New drugs that block the PD-L1 protein, or the corresponding PD-1 protein on immune cells called T cells, can help the immune system recognize the cancer cells and attack them.

In early studies, an anti-PD-1 drug known as nivolumab shrank tumors in about 1 out of 5 people with NSCLC, while a drug targeting PD-L1 (known as BMS-936559) shrank tumors in about 1 out of 10 people. Many of the tumor responses have been long-lasting so far. Larger studies of these and other, similar new drugs are now being done, but they are still only available in clinical trials.

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Software Recovery

The following is a transcript of an interview with Graham Henley, one of the founders of GetData and authors of Recover My Files:

Q; Why, if data recovery software technology is so readily available, aren’t the overwhelming majority of us aware that it’s possible?

Well basically it is because the button on the keyboard says “delete”. Most computer users take this at face value and think that when you press the delete button it’s gone for ever, which is not the case.

Also we have all become very used to the Windows Recycle Bin, where you can move files that you no longer want, but can get them out before you empty the bin. Many people still don’t realize that with data recovery, even when the Recycle Bin is emptied there is still an opportunity to recover the files.

Q: How is it possible to recover missing files without sending your drive out to a company and risk something happening to the drive? (Or….Why is it not necessary to send your drive out to a company to recover your files?)

Data recovery can be put into two categories …

  • when your computer hard drive is working perfectly, but you have deleted files, formatted your drive, or lost your data for some other reason. This is what is referred to in the industry as a “logical” problem.
  • when you computer hard drive has physical errors and some of the mechanical or electrical components of the drive no longer work, for example when you computer has been in a fire or a flood. This is what is referred to in the industry as a “physical” problem.

In many cases the data has been lost due to a “logical” problems and a software solution can be used to recover files. It is only if you drive has physical errors that you need to send it to a hardware recovery service.

Q: In simple terms, what is the technology that allows a computer owner to recover their files right there at their desk?

Data recovery is possible because of the way the Microsoft Windows operating system is designed. Historically Windows has been developed to maximize the speed of computer use. Permanent erasure of data, whilst possible, takes time.

Q: What was the technical breakthrough that allows us to do this now?

Data recovery procedures have improved rapidly in recent years. A lot of this is due to the need by law enforcement agencies around the world to deal with electronic evidence.

 

 

Q: Is the ability to recover files limited to conventional hard-drives, or can files be recovered from other types of drives or media on which information may be stored

Files can be recovered from many different types of media, including hard drive, USB drives and digital camera storage cards.

Q: What risks are there to downloading a software application and having it search and recover your missing or deleted files?

When you download files from the Internet to your computer you should always make sure the file comes from a trusted source, no matter what the software does. This is a good basic security policy for your computer and will protect you from such things like viruses and spyware.

If you are looking for data recovery software you should make sure that:

  • the software you use does NOT change the contents of the drive being searched. If the software does not work you want to be able to pursue other options to try and get your valuable data back.
  • It is possible that deleted data can be destroyed and not recovered. You should be able to identify that the data recovery software has recovered your data before you purchase it. Recover My Files does this by having a file preview window which allows you to view pictures and documents.

Q: What sort of files will the data recovery software find?

Recover My Files can find any type of deleted file, but it also has support for more than 200 specific file types file. There are two methods to data recovery:

1. Every file on a computer, even the deleted ones, is identified by a record in a table called the Master File Table or MFT. A files MFT record tells the computer the name of the file and also the location on the disk where the file is stored. Recover My Files reads these MFT records to find and recover deleted or lost files.

2. In some circumstances the MFT records can become corrupt or destroyed. In this situation Windows has no reference information to locate the deleted or lost files, however, Recover My Files can look for and find user specified file types by scanning the storage media and looking for a files unique structure, that is, it’s unique header, content and footer.

 

 

Q: Does it take long, and could I keep working on my computer while the data recovery software is working?

You should limit the use of the computer until data recovery is finished. The more you use a computer the more chance you have of writing data to the storage media and overwriting and destroying deleted files that could have otherwise been recovered.

In some situations data recovery can take time. With a very large hard drive of 200GB, it may take up to 15 hours to search the entire disk.

Q: How do I begin and stop the software searching?

Recover My Files if straight forward to use. There are basically four steps.

1. Decide what search you want to run according to your situation, for example whether you have deleted files or formatted your drive.

2. Select the drive that you want to search. If you can no longer see a drive letter, Recover My Files allows you to search a drive at a “physical level”, meaning that it finds drive in your PC, starts at the beginning and goes to the end, ignoring all drive letters on the drive;

3. Select the specific file types, if any, that you are looking for;

4. Start the search and preview and save the results.

Q: How will I know if the software has found my missing files?

You will be able to see the file names and click on the recovered files to preview them.

 

 

Q: What do I do once the software has found them?

Select the files that you wish to save and then save them to another drive. You need to activate the program in order to do this, which means purchasing an activation key from www.recovermyfiles.com. The activation key I given to you at the time of your purchase so you can save the files straight away.

Q: Can I use the data recovery software over and over, if I have future problems with missing files, or is it a once-off?

Once you purchase Recover My Files you can use it over and over again. An activation key is valid for installation on two computers, for example, a desktop and a laptop.

from: recovermyfiles.com

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Tax Haven Countries

PANAMA, OFF SHORE, There are lots of countries if you want to hide your real income. They offers very profitable, tax free rates. Only thing you should do choose an off shore plan, give all your savings and enjoy. The European Union has discharged a boycott of 17 nations which it says are duty sanctuaries, following 10 months of examinations by authorities.After a gathering in Brussels on Tuesday EU back pastors said American Samoa, Bahrain, Barbados, Grenada, Guam, South Korea, Macau, Marshall Islands, Mongolia, Namibia, Palau, Panama, Saint Lucia, Samoa, Trinidad and Tobago, Tunisia and the United Arab Emirates are not doing what’s necessary to take action against seaward evasion plans.

Vitally for the UK, the primary rundown avoids various British Overseas Territories, for example, the Cayman Island and Bermuda that were on a past EU boycott from June 2015. Grumblings about the philosophy of that last rundown saw it rejected and supplanted with the new enlist.

The absence of settled assessment safe houses from the rundown, be that as it may, drove some MEPs and hostile to charge shirking efforts to mark it a “whitewash”.

The new rundown was drafted by the European Council’s Code of Conduct (COC), a gathering involved back pastors from EU part states, including the UK. Nations’ incorporation depends on whether a state gives particular treatment to organizations empowering them to move benefits to maintain a strategic distance from charges.

Another 47 nations have additionally been incorporated into a “dim” rundown of nations not consistent with EU charge principles but rather who have resolved to change their guidelines. These nations should embrace EU administers before the finish of 2018, or 2019 for creating nations, to abstain from being incorporated into the fundamental rundown.

“This activity is as of now demonstrating its esteem, as various nations have attempted to meet the due date for making responsibilities based on our criteria”, said Toomas Tõniste, serve for fund of Estonia, which right now holds the European Council administration.

“Be that as it may, it is likewise imperative that we intently screen the usage of duties made by our accomplices around the globe.”

“This isn’t only an irregular procedure. We will routinely audit and refresh the rundown in the years to come. Our point is to guarantee that great assessment administration turns into the new standard.”

“We have received at EU level a rundown of states which are not doing what’s necessary to battle tax avoidance,” French back clergyman Bruno Le Maire said.

Pierre Moscovici, official for monetary and budgetary issues, tax collection and traditions, stated: “The selection of the principal ever EU boycott of expense safe houses denotes a key triumph for straightforwardness and decency.

 

“Be that as it may, the procedure does not stop here. We should increase the weight on recorded nations to alter their way of living.

“Boycotted wards must face outcomes as dissuasive assents, while those that have made duties must catch up on them rapidly and solidly. There must be no naivety: guarantees must be transformed into activities. Nobody must get a free pass.”

Individuals from the European Parliament and campaigners anyway condemned the nonappearance of specific nations from the rundown.

“It undermines the EU’s validity that Member States were just ready to concede to a whitewashed boycott of assessment sanctuaries,” said Sven Giegold, financial aspects representative for the Green gathering.

“Not a standout amongst the most vital assessment sanctuaries has been put on the rundown. The rundown is politically one-sided as significant monetary focuses like the United States of America are absent.”

“Instead of have a rundown of duty sanctuaries in view of a target set of criteria, as initially imagined, the rundown gives off an impression of being a political fix with EU individuals picking their minimum most loved nations to name and disgrace,” said Alex Cobham, CEO of the Tax Justice Network.

“The aftereffect of the imperfect boycotting process is a politically driven rundown, that incorporates just the monetarily frail and politically detached.

from: independent.co.uk

Top Tax Havens in the World

  • Bermuda – Declared the world’s worst (or best if you’re looking to avoid taxation) corporate tax haven in 2016 by Oxfam with zero percent tax rate and no personal income tax.
  • Netherlands – Most popular tax haven among the world’s Fortune 500. The government uses tax incentives to attract businesses to invest in their country. One such tax incentive cost an estimated 1.2 billion euros in 2016 to Netherlands.
  • Luxembourg – It gives benefits such as tax incentives and zero percent withholding taxes.
  • Cayman Islands – No personal income taxes, no capital gains taxes, no payroll taxes, no corporate taxes, and the country does not withhold taxes on foreign entities.
  • Singapore – Charges reasonable nominal corporate taxes. Reasonable corporate tax rates are provided through tax incentives, lack of withholding taxes, and what appears to be substantial profit shifting.
  • The Channel Islands – No capital gains taxes, no council taxes, and no value added taxes.
  • Isle of Man – No capital gains tax, turnover tax. or capital transfer tax. It also imposes a low income tax, with the highest rates at 20%.
  • Mauritius – Low corporate tax rate and no withholding tax.
  • Switzerland – Full or partial tax exemptions depending on the bank used.
  • Ireland – Referred to as a tax haven despite officials asserting that it is not. Apple discovered that two of the company’s Irish subsidiaries were not classified as tax residents in the United States or Ireland, despite being incorporated in the latter country.

from: corporatefinanceinstitute.com

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Luxury lifestyle essentials: Yachts, mansions, luxury cars, private planes, social life…

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It’s expensive being rich

Living the rich life can cost you. And the more you have, the more you’ll spend. Click on the image above to see what a super rich lifestyle can cost.Many people dream of someday making enough money to be able to buy whatever they want, and never having to worry again.But the reality is that having a lot of money costs a lot of money, and living a wealthy lifestyle doesn’t come cheap. Not only do bigger houses, luxury cars and better schools cost more, but the everyday cost of maintaining fancier things can really add up.

Household help

While maid service may seem like a luxury, bigger houses are much harder to keep clean, especially if you’re working long hours to pay the huge mortgage. Chances are, you’re going to need a housekeeper to tidy up and be home once your children return from private school.Having a housekeeper for just a few hours each week day can add up to more than $20,000 a year, according to Quintessentially People, a group that helps wealthy clients find household staff.

Add on a few thousand bucks for someone to tend to your yard every week or so. Standard landscaping maintenance for yards from a half acre up to three acres can cost $1,500 to $3,000 per month, Keith Williams, a landscape architect in Palm Beach, Fla.,

Schools

Many wealthy families feel it necessary to forgo public schools — with their larger classes and more limited resources — in favor of private schools with smaller classes, Olympic-sized pools and highly-educated teachers who speak Mandarin.

But that choice costs a pretty penny — the average nationwide cost of private school tuition is nearly $11,000, according to the National Center for Education Statistics.
In some pricier areas like New York, it can cost up to $40,000 per year for each kid — or about the cost of a year of college, according to Amanda Uhry, founder of Manhattan Private School Advisors.

Utilities

Everyone has to pay to keep the lights and heat on. But the more rooms you have to light and heat, the more sinks and showers you have to keep water running, the more expensive your bill. Sonja Morgan, the famed Real Housewife of New York City, said she pays $1,400 in utilities per month for her 4,800-square-foot townhouse on New York’s Upper East Side.
“Is that a lot?” she asked in an interview at her dining room table.
In comparison, utilities for a 425-square-foot studio apartment would cost just under $50.

Driving

Most wealthy people can afford to drive nicer cars than the rest of us. But if you have a luxury car, you’ll usually end up paying more for premium gas, repairs and maintenance. Just getting your car serviced can cost as much as $400 for a Mercedes S Class, vs. $60 for a Honda Civic, according to estimates from U.S. News and World Report. And if you own a car in a major city like New York, you’re likely paying more than $30,000 annually just to park it in a garage.

The really rich life

The operating costs of being rich get even higher the more money you have. Those who have enough change to have a second home, a driver, a private plane or even a yacht, pay more than most people make in a year, just to maintain those things.

For example, the super rich may need a personal assistant for about $90,000 per year, and a chef to cook for their busy family, at about $100,000, according to Quintessentially People. The pilot on your private plane will run you about $300,000, and the flight attendant another $150,000. For just a couple months on your yacht, you’re shelling out $44,000 for the crew alone. “These people are essential to our wealthy clients,” said Samuel Martin, co-founder of Quintessentially People. “These people require this kind of support.”

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Photographing The Stars is Like “Jumping in The Time And Space”

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Consider you made an enjoyable photo shooting last night including the Pole Star. Moreover consider you had a quality printout of the photograph then hanged it on a wall of your home… Congratulations! You traveled through time. The picture on your wall is at least from 450 years ago.

No, I didnt make a sentence with incoherency. If you took a star photo, the image you got belongs to hundreds of year ago ... Well then, how did it happen? You should know that the distance to earth of objects on the sky or in the universe, of we take the photos or see with naked eye, is calculated in terms of light years. Now, thinkabout the time it takes the light, in other words the image, arrives to us... Hundreds of years elapse in the earth before image of the star reaches us.

How is star exposure made?

After summarizing the sides of the matter like past, time and light, which sounds somewhat unfamiliar, we can switch to some practical information on photography. In this section, I will talk about a technique in which we adapt long exposure shoot to stars: Star Exposure.

The shutterspeed on our cameras ensures us freeze time in different sections. I usually clarify the matter to beginners using the example of blink of an eye. Consider that the duration when life enters increases while the eye of a person stays open. As you know, if you keep your eyes open beyond certain duration your eyes stream. Well, what happens in photography? If you are in a setting where is dark enough, if you keep your eyes open more, you see that everywhere lightens…

The shutter speed of cameras is similar. Long exposure is comparable to your friend who can keep eyes open to be able to see even in the dark. High shutter speed is your tiqueur friend who blinks continually... When exposing stars, we are going to imitate your friend possessing the most useless super hero power ever, who can keep her eyes open for a long time in order to be able to see in the utter darkness.

In order to be able to take a clear photo of a quick-moving object, we first of all need sufficient light and then a high shutter speed. On the other hand, in times when we need more light for exposure, we need a steady speed and a lower shutter speed. That is to say, not only time, but we also need a steady speed. In summary, while taking star photos, your camera should look at the sky longer without blinking or moving.

Sure, there are other things that we should take into consideration during long exposure. If you have ever flown at night, you should have noticed how strong the rising city lights were when you have looked down. Those city lights and similar light sources are the primary physical elements that we should avoid when shooting the stars.

Photographing The StarsIn case any light other than that emitted by the celestial bodies themselves enters in your photo frame, it will impair the quality of your photo or might completely damage your photo. Besides the light source issue, I should also remind that, using the lunar calendar we should prefer times when no strong light source like moon is quite close to Earth.

Moreover, because the shutter of your camera will have to be open for an average of one to three hours, it should certainly be stable in the meantime. If you don’t have a high quality tripod or if you cant keep your camera stable during exposure, it is of very low possibility that you will be successful.

I know that I am explaining a bit complicated, but don’t worry. I’m going to summarize. Let me give you a step by step guide about what you should take into consideration related to star exposure.

You must shoot away from city lights.

The sky should be clear and the Moon shouldn’t be at the top. Because you will make long exposure, you must have a tripod that can prevent camera shake. Carbon fiber ones can considerably reduce shake.

In order to prevent shakes whenever you press the shutter and in order to be able to use the ‘bulb’ mode if it isn’t taking place on your camera, you must have a cable trigger. If you want to convey the motion of stars on your photo, you might use longer exposure duration. If you want to shoot the stars as is, as points, you might use a much more shorter exposure duration.

Your ISO/ASA value should be as low as possible. Long exposure=sensor getting warmer=more noise. In order to avoid it we should use the lowest possible ISO values.

If they take place on your lens, you must turn off anti flicker and auto-focusing.

Photographing The StarsDo not attempt to increase aperture to values like f22, or you unnecessarily lengthen the wait time for hours.

Do not go desolate places posing risk for you just for the sake of moving away from city lights. If you are going somewhere like a village or town, do not forget to tell people that you are going to shoot. Otherwise, the owner of the territory that you entered in the night time is likely to assume what you are holding is a gun and react you! I should repeat that it is not a joke, but a serious warning.

You should set the exposure duration based on your experiences, the circumstances and the photo you wish to get. Do not afraid from trial and error. The above stated duration of one hour is exemplary.

Finally, you must use the sentences like “May be most of the stars that we see now went out a long time agoonly at romantic moments with your darling. Because, the stars within our visual space have millions of years to die and they will probably stay there after our planet disappear. If you are not making a telescopic shoot, you take the photo of past rather than of
the lost and gone forever.

As a last word, I should say that I wrote this article not as a scientist but as an ‘advertising photographer-director’ who is interested in space and science...

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